Case Studies In Multiple Sclerosis: Taking A Fresh Look At A Complex Disease

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Claiming CME/CE Credits

To receive CME/CE credits, participants must review the program materials in their entirety and complete the online post examination and evaluation with a score of 70% or better.

System Hardware/Software and Internet Connection Requirements

The following information is provided for your reference in conjunction with review of this program.

General System and Internet Requirements:  Speakers or Headphones, High Speed Internet connection, Wireless 3G and 4G.
Web browsers: Internet Explorer 7.x or higher, Firefox 4.x or higher, Safari 2.x or higher and Chrome.

Operating Systems:  Windows 2000 or higher, (MS Surface and other MS mobile devices compatible), MAC OSX 10.3 or higher, Mac iOS 5.0 or higher (iPad, iPhone compatible), Android 4.3 or higher (most Android mobile devices compatible).

Effective Date: December 15, 2018
Expiration Date: December 15, 2019
Format: Self Instructional - Audio Visual Voice-Over with Slides
Maximum Credits: 1.0 AMA PRA Category 1 CME Credit™ , 1.0 Nursing Contact Hours (1.0 Pharmacotherapeutic Hours), 1.0 Pharmacy CE (Knowledge Based)
Estimated Completion Time: 1 hour

This program provides the knowledge and skills to primary care providers (PCPs) to enable them to correctly diagnose and treat multiple sclerosis (MS) and its co-morbidities for improved patient outcomes. It covers assessment protocols and diagnostic tests: pharmacologic, alternative, and complementary therapies; patient monitoring; and symptom management. Four case study discussions are presented in15 minute interactive, voice-over slides lectures. Two toolkits are available for download, one for the PCP and one for the patient.

Case One - Presenting Symtoms of Multiple Sclerosis:
Covers the essentials of the history and neurological exam and descriptions of symptoms of optic neuritis, transverse myelitis, and brainstem and cerebellar involvement.

Case Two - Current Diagnostic Tests:
Covers the current diagnostic tests, including lab and imaging, are presented and shown as well as major clinical red flags in diagnosis.

Case Three - Current Pharmacologic, Non-Pharmacologic Treatment Options:
Covers the common principles of MS therapy, injectables, oral medications, and IV infusions: their side effects, monitoring, and risks are discussed as well as disease-modifying therapies for relapsing remitting MS. Non-pharmacological treatment includes diet, exercise, and mental health.

Case Four - Patient Monitoring and Symptom Management:
Covers the managing motor and other symptoms (eg, bladder, fatigue, pain, and mood) as discussed. Use of the toolkits to help the patient to manage their own symptoms and find resources.

Target Audience

This program is intended for Primary Care Physicians, Physician Assistants, Nurse Practitioners, Nurses, Pharmacists and Other Health Care Professionals.


To enable the healthcare provider to correctly manage the patient with MS for better outcomes.

Outcome Objectives

Upon conclusion of this CME/CE activity participants will be able to:

  1. Discuss the typical and atypical signs and symptoms of MS as the first stage in assessment of the disease.
  2. Recommend appropriate diagnostic testing and apply the current criteria for diagnosing MS
  3. Manage motor and psychologic symptoms associated with MS
  4. List the principle medications and IV infusions used to treat MS along with their side effects and risks, in addition to, non-pharmacologic treatments

Patient & Professional Toolboxes

View/Download Toolkits:  PCP Tookit   /   Patient Toolkit
(PDF files, links will open in new window)

Presented by

Pavle Repovic, MD, PhD Pavle Repovic, MD, PhD
American Board of Psychiatry and Neurology
Multiple Sclerosis Center
Swedish Neuroscience Institute
Seattle, WA

Pavle Repovic, MD, PhD, is a neurologist at the Multiple Sclerosis Center, Swedish Neuroscience Institute in Seattle, Washington. He received his medical degree and PhD from the University of Alabama School of Medicine. Prior to completing his postdoctoral training in neurology at Mount Sinai Medical Center in the Corinne-Goldsmith Dickinson Center for Multiple Sclerosis, he finished his residency in neurology at Weill Cornell Medical College. In addition to his educational achievements, he is also an active member of numerous professional organizations including the American Academy of Neurology and the Washington State Neurological Society. His research in multiple sclerosis and neurochemistry has been recognized in book chapters and numerous peer-reviewed scientific journals including the Journal of Neuroscience and the Journal of Neurochemistry. He has been awarded the Sylvia Lawry Fellowship from the National MS Society and the Young Investigator Fellowship from the International Society for Neurochemistry. In addition, he has served as President of the Medical Student Research Society at the University of Alabama School of Medicine. His teaching activities include serving as the clinical preceptor for University of Washington medical students. Throughout his career, he has been invited as a guest speaker to present his work in neuroimmunology at conferences worldwide.

Conflict of Interest Disclosure Policy

It is the policy of the Foundation for Care Management (FCM) to ensure independence, balance, objectivity, scientific rigor, and integrity in all of its continuing education activities. FCM requires everyone in a position to control the content of this activity to disclose any relevant financial conflicts of interest they may have as related to the content of this activity and having occurred within the last 12 months. The faculty must disclose to the participants any significant relationships with commercial interests whose products or devices may be mentioned. All identified conflicts of interest are thoroughly vetted by FCM for fair balance, scientific objectivity of studies mentioned in the material or used as the basis for content, and appropriateness of patient care.

“A commercial interest is any entity producing, marketing, re-selling, or distributing health care goods or services consumed by or used on patients.”



Dr. Repovic is a Speaker/Consultant for Biogen Idec, and Teva. He is a Consultant for Genzyme and a Speaker for EMD Serono/Pfizer and also a Speaker/Consultant/Investigator for Novartis.

FCM’s Planning Committee:

Jeanette M. Dunn, RN, MSN, EdD, Lead Nurse Planner; Lisa Chamberlain, PharmD, have no financial interest in any of the products or manufacturers mentioned.

Dr. Repovic, content expert - see disclosure above.


AMA PRA Category 1 Credit(s)™

Accreditation Statement: The Foundation for Care Management (FCM) is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for Physicians.

Designation Statement: FCM designates this educational activity for a maximum of 1.0 AMA PRA Category 1 credits™. Physicians should only claim credit commensurate with the extent of the participation in the activity.

CE for Pharmacists

Accreditation Statement: ACPE Logo The Foundation for Care Management is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Program # 0347-0000-15-012-H01-P. All objectives are appropriate for pharmacists
* This CE activity is knowledge-based.

CE for Nurses

Accreditation Statement: The Foundation for Care Management is an approved provider of continuing nursing education by the Western Multi-State Division (WMSD), Approver of Continuing Nursing Education an accredited approver by the American Nurses Credentialing Center’s Commission (ANCC) on Accreditation.

Method of Participation/Criteria for Success

To receive CME/CE credits, participants must review the program materials in their entirety and complete the online post examination and evaluation with a score of 70% or better. A statement of credit will be available for printing upon successful completion.

If you have questions about this CME/CE activity, please contact FCM at


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

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